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https://doi.org/10.1039/b923331h
Title: | The use of click chemistry in the emerging field of catalomics | Authors: | Kalesh, K.A. Shi, H. Ge, J. Yao, S.Q. |
Issue Date: | 2010 | Citation: | Kalesh, K.A., Shi, H., Ge, J., Yao, S.Q. (2010). The use of click chemistry in the emerging field of catalomics. Organic and Biomolecular Chemistry 8 (8) : 1749-1762. ScholarBank@NUS Repository. https://doi.org/10.1039/b923331h | Abstract: | Of the thousands of known chemical reactions, a handful of reactions, called "click" reactions, stand out with features such as good chemoselectivity, good solvent compatibilities, modularity, minimum synthetic demands, bioorthogonality and high yields. Among them, the Cu(i)-catalyzed 1,3-dipolar cycloaddition reaction between azides and terminal alkynes has emerged as a powerful tool in chemical biology and proteomics. This perspective surveys the significant contributions of click chemistry in catalomics (a sub-area in chemical proteomics), with special emphasis on activity-based protein profiling (ABPP), posttranslational modifications (PTMs) and enzyme inhibitor developments. © 2010 The Royal Society of Chemistry. | Source Title: | Organic and Biomolecular Chemistry | URI: | http://scholarbank.nus.edu.sg/handle/10635/95273 | ISSN: | 14770520 | DOI: | 10.1039/b923331h |
Appears in Collections: | Staff Publications |
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