The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives

Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.201006316

Title:	The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives
Authors:	Luo, J. Wang, H. Han, X. Xu, L.-W. Kwiatkowski, J. Huang, K.-W. Lu, Y.
Keywords:	aldol reaction asymmetric synthesis butenolides glycerol derivatives organocatalysis
Issue Date:	18-Feb-2011
Citation:	Luo, J., Wang, H., Han, X., Xu, L.-W., Kwiatkowski, J., Huang, K.-W., Lu, Y. (2011-02-18). The direct asymmetric vinylogous aldol reaction of furanones with α-ketoesters: Access to chiral γ-Butenolides and glycerol derivatives. Angewandte Chemie - International Edition 50 (8) : 1861-1864. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.201006316
Abstract:	Twice as good: The title reaction using the tryptophan-derived bifunctional organic catalyst 1 has been developed. The reported method led to the synthesis of chiral γ-substituted butenolides in excellent yields, with high diastereo- and enantioselectivities. Facile synthesis of chiral glycerol derivatives containing a tertiary hydroxy group has also been demonstrated. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title:	Angewandte Chemie - International Edition
URI:	http://scholarbank.nus.edu.sg/handle/10635/95219
ISSN:	14337851
DOI:	10.1002/anie.201006316
Appears in Collections:	Staff Publications

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