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|Title:||Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate||Authors:||Chng, S.-S.
Wayne Lee, W.-W.
|Issue Date:||20-Dec-2004||Citation:||Chng, S.-S., Hoang, T.-G., Wayne Lee, W.-W., Tham, M.-P., Ling, H.Y., Loh, T.-P. (2004-12-20). Synthetic studies towards anti-SARS agents: Application of an indium-mediated allylation of α-aminoaldehydes as the key step towards an intermediate. Tetrahedron Letters 45 (52) : 9501-9504. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2004.10.146||Abstract:||AG7088 was identified as a good starting point for modification, leading to an efficient and bio-available inhibitor for the SARS coronavirus main proteinase (SARS-CoV M pro). Synthesis of intermediate 1 and analogues proceeded via a highly diastereoselective indium-mediated allylation of α-aminoaldehydes. © 2004 Elsevier Ltd. All rights reserved.||Source Title:||Tetrahedron Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/95185||ISSN:||00404039||DOI:||10.1016/j.tetlet.2004.10.146|
|Appears in Collections:||Staff Publications|
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