Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0277-5387(02)01045-8
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dc.titleSynthesis, X-ray structures, and cytotoxicity of rhenium(I) carbonyl 2-(dimethylamino)ethoxide complexes
dc.contributor.authorWang, W.
dc.contributor.authorYan, Y.K.
dc.contributor.authorAndy Hor, T.S
dc.contributor.authorVittal, J.J.
dc.contributor.authorWheaton, J.R.
dc.contributor.authorHall, I.H.
dc.date.accessioned2014-10-16T08:44:44Z
dc.date.available2014-10-16T08:44:44Z
dc.date.issued2002-09-01
dc.identifier.citationWang, W., Yan, Y.K., Andy Hor, T.S, Vittal, J.J., Wheaton, J.R., Hall, I.H. (2002-09-01). Synthesis, X-ray structures, and cytotoxicity of rhenium(I) carbonyl 2-(dimethylamino)ethoxide complexes. Polyhedron 21 (20) : 1991-1999. ScholarBank@NUS Repository. https://doi.org/10.1016/S0277-5387(02)01045-8
dc.identifier.issn02775387
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/95179
dc.description.abstractThe complexes [Re(η2-Me2NCH2CH2O) (CO)3(μ-OH)Re(η2-Me2 NCH2CH2OH)(CO)3] (1) and [Re3(μ3-OH)(μ-OH)2(μ-OCH2 CH2NMe2H)(CO)9] (2) have been synthesised and characterised by single-crystal X-ray diffraction analysis. Complex 1 exists as hydrogen-bonded dimers in the solid state and in solution. Proton NMR, 1H-1H COSY and NOESY spectroscopic studies showed that the structure of 1 is static in solution, and that only one of the many possible geometric isomers of 1 exists. The hydrogen atom on the ammonio nitrogen of 2 is involved in intramolecular N-H⋯O hydrogen-bonding with a bridging OH group. Complexes 1 and 2 were shown to be potent in suspended tumour cell lines in suppressing growth but were more selective in inhibiting the growth of cultures from solid tumours. The compounds [NBun 4][ReO4] and [NEt4]2[ReBr3(CO)3] were also very active against the suspended cell lines and selective against solid tumours. All the compounds tested are inactive against normal cells. © 2002 Elsevier Science Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0277-5387(02)01045-8
dc.sourceScopus
dc.subjectAminoalcohol
dc.subjectCarbonyl
dc.subjectCytotoxicity
dc.subjectHydrogen-bonding
dc.subjectOxidative-alkoxylation
dc.subjectRhenium(I)
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/S0277-5387(02)01045-8
dc.description.sourcetitlePolyhedron
dc.description.volume21
dc.description.issue20
dc.description.page1991-1999
dc.description.codenPLYHD
dc.identifier.isiut000178269000004
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