Please use this identifier to cite or link to this item:
|Title:||Syntheses, characterizations, and a preliminary comparative cytotoxicity study of gold(I) and gold(III) complexes bearing benzimidazole- and pyrazole-derived N-heterocyclic carbenes||Authors:||Sivaram, H.
|Issue Date:||27-Aug-2012||Citation:||Sivaram, H., Tan, J., Huynh, H.V. (2012-08-27). Syntheses, characterizations, and a preliminary comparative cytotoxicity study of gold(I) and gold(III) complexes bearing benzimidazole- and pyrazole-derived N-heterocyclic carbenes. Organometallics 31 (16) : 5875-5883. ScholarBank@NUS Repository. https://doi.org/10.1021/om300444c||Abstract:||A series of Au(I) and Au(III) mono-, homobis-, and heterobis(carbene) complexes, [AuCl(FPyr)] (2), [Au( iPr 2-bimy) 2]PF 6 (3), [Au(FPyr) 2]PF 6 (4), [Au(FPyr)( iPr 2-bimy)]PF 6 (5), [AuCl 3( iPr 2-bimy)] (6), [AuCl 3(FPyr)] (7), [AuCl 2( iPr 2-bimy) 2]PF 6 (8), [AuCl 2(FPyr) 2]PF 6 (9), and [AuCl 2(FPyr)( iPr 2-bimy)]PF 6 (10), bearing the benzimidazole-derived iPr 2-bimy (1,3-diisopropylbenzimidazolin-2-ylidene) and/or the pyrazole-derived FPyr (1,2,3,4,6,7,8,9-octahydropyridazino[1,2-a]indazolin-11-ylidene) N-heterocyclic carbene (NHC) ligands have been synthesized. Complexes 2-10 have been fully characterized using multinuclei NMR spectroscopy, ESI mass spectrometry, and elemental analysis. X-ray diffraction analyses have been performed on 2, 3, 5, 6, and 8. Together with the previously reported [AuCl( iPr 2-bimy)] (1), the cytotoxic activities of all 10 complexes have been studied in vitro with the NCI-H1666 non-small cell lung cancer cell line. The cationic bis(carbene) complexes 3-5 and 8-10 show better cytotoxicity in comparison to cisplatin. In particular, the heterobis(carbene) complexes 5 and 10 have superior activity, with IC 50 values of around 0.2 μM. © 2012 American Chemical Society.||Source Title:||Organometallics||URI:||http://scholarbank.nus.edu.sg/handle/10635/95017||ISSN:||02767333||DOI:||10.1021/om300444c|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 14, 2021
WEB OF SCIENCETM
checked on Jun 14, 2021
checked on Jun 8, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.