Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol052895w
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dc.titleRapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases
dc.contributor.authorSrinivasan, R.
dc.contributor.authorUttamchandani, M.
dc.contributor.authorYao, S.Q.
dc.date.accessioned2014-10-16T08:38:32Z
dc.date.available2014-10-16T08:38:32Z
dc.date.issued2006-02-16
dc.identifier.citationSrinivasan, R., Uttamchandani, M., Yao, S.Q. (2006-02-16). Rapid assembly and in situ screening of bidentate inhibitors of protein tyrosine phosphatases. Organic Letters 8 (4) : 713-716. ScholarBank@NUS Repository. https://doi.org/10.1021/ol052895w
dc.identifier.issn15237060
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/94651
dc.description.abstractWe have successfully designed and synthesized a small library of protein tyrosine phosphatase (PTP) inhibitors, in which the so-called "click chemistry" or Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction was carried out for rapid assembly of 66 different bidentate compounds. Subsequent in situ enzymatic screening revealed a potential PTP1B inhibitor (IC50 = 4.7 μM) which is 10-100 fold more potent than other PTPs. © 2006 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/ol052895w
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/ol052895w
dc.description.sourcetitleOrganic Letters
dc.description.volume8
dc.description.issue4
dc.description.page713-716
dc.identifier.isiut000235534800042
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