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Title: POE/PLGA composite microspheres: Formation and in vitro behavior of double walled microspheres
Authors: Yang, Y.-Y.
Shi, M. 
Goh, S.-H. 
Moochhala, S.M.
Ng, S.
Heller, J.
Keywords: Double walled microspheres
Poly(ortho esters)
Polymer degradation
Issue Date: 7-Mar-2003
Citation: Yang, Y.-Y., Shi, M., Goh, S.-H., Moochhala, S.M., Ng, S., Heller, J. (2003-03-07). POE/PLGA composite microspheres: Formation and in vitro behavior of double walled microspheres. Journal of Controlled Release 88 (2) : 201-213. ScholarBank@NUS Repository.
Abstract: The poly(ortho ester) (POE) and poly(D,L-lactide-co-glycolide) 50:50 (PLGA) composite microspheres were fabricated by a water-in-oil-in-water (w/o/w) double emulsion process. The morphology of the composite microspheres varied depending on POE content. When the POE content was 50, 60 or 70% in weight, the double walled microspheres with a dense core of POE and a porous shell of PLGA were formed. The formation of the double walled POE/PLGA microspheres was analysed. Their in vitro degradation behavior was characterized by scanning electron microscopy, gel permeation chromatography, Fourier-transform infrared microscopy and nuclear magnetic resonance spectroscopy (NMR). It was found that compared to the neat POE or PLGA microspheres, distinct degradation mechanism was achieved in the double walled POE/PLGA microspheres system. The degradation of the POE core was accelerated due to the acidic microenvironment produced by the hydrolysis of the outer PLGA layer. The formation of hollow microspheres became pronounced after the first week in vitro. 1H NMR spectra showed that the POE core was completely degraded after 4 weeks. On the other hand, the outer PLGA layer experienced slightly retarded degradation after the POE core disappeared. PLGA in the double walled microspheres kept more than 32% of its initial molecular weight over a period of 7 weeks. © 2003 Elsevier Science B.V. All rights reserved.
Source Title: Journal of Controlled Release
ISSN: 01683659
DOI: 10.1016/S0168-3659(02)00491-1
Appears in Collections:Staff Publications

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