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|Title:||Kinetic studies of mercuric chloride on Na+ K+-ATPase in the kidney of fancy carp, Cyprinus carpio||Authors:||Lan, W.G.
|Issue Date:||Jul-1993||Citation:||Lan, W.G.,Wong, M.K.,Sin, Y.M. (1993-07). Kinetic studies of mercuric chloride on Na+ K+-ATPase in the kidney of fancy carp, Cyprinus carpio. Comparative Biochemistry and Physiology -- Part B: Biochemistry and 105 (3-4) : 713-717. ScholarBank@NUS Repository.||Abstract:||1. 1. The effect of mercuric chloride on the substrate and ionic activation kinetics of Na+ K+-ATPase activity in the kidney of fancy carp (Cyprinus carpio) was determined. 2. 2. Mercuric inhibition was shown to be a classical competitive nature with respect to substrate ATP activated Na+ K+-ATPase, in that the apparent Km values were increased without a significant change in the apparent Vmax values. 3. 3. Mercuric inhibition was a mixed noncompetitive nature with respect to Na+-activated Na+ K+-ATPase, where the apparent Km values were increased but the apparent Vmax values were decreased. 4. 4. Mercuric inhibition was a pure noncompetitive nature with respect to Mg2+ and K+-activated Na+ K+-ATPase, in that the apparent Vmax values were decreased but not the apparent Km values. 5. 5. Based on the above results, we proposed a possible kinetic model for elucidating the biochemical mechanism of inhibition of mercuric chloride on Na+ K+-ATPase in the kidney of fancy carp. © 1993.||Source Title:||Comparative Biochemistry and Physiology -- Part B: Biochemistry and||URI:||http://scholarbank.nus.edu.sg/handle/10635/94121||ISSN:||03050491|
|Appears in Collections:||Staff Publications|
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