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Title: Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles
Authors: Deng, R.
Xie, X.
Vendrell, M.
Chang, Y.-T. 
Liu, X. 
Issue Date: 21-Dec-2011
Citation: Deng, R., Xie, X., Vendrell, M., Chang, Y.-T., Liu, X. (2011-12-21). Intracellular glutathione detection using MnO 2-nanosheet- modified upconversion nanoparticles. Journal of the American Chemical Society 133 (50) : 20168-20171. ScholarBank@NUS Repository.
Abstract: We report a novel design, based on a combination of lanthanide-doped upconversion nanoparticles and manganese dioxide nanosheets, for rapid, selective detection of glutathione in aqueous solutions and living cells. In this approach, manganese dioxide (MnO 2) nanosheets formed on the surface of nanoparticles serve as an efficient quencher for upconverted luminescence. The luminescence can be turned on by introducing glutathione that reduces MnO 2 into Mn 2+. The ability to monitor the glutathione concentration intracellularly may enable rational design of a convenient platform for targeted drug and gene delivery. © 2011 American Chemical Society.
Source Title: Journal of the American Chemical Society
ISSN: 00027863
DOI: 10.1021/ja2100774
Appears in Collections:Staff Publications

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