Please use this identifier to cite or link to this item: https://doi.org/10.1142/S0192415X13500572
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dc.titleHypoglycemic activities of commonly-used traditional Chinese herbs
dc.contributor.authorFeng, S.
dc.contributor.authorSong, L.
dc.contributor.authorLiu, Y.
dc.contributor.authorLai, F.
dc.contributor.authorZuo, G.
dc.contributor.authorHe, G.
dc.contributor.authorChen, M.
dc.contributor.authorHuang, D.
dc.date.accessioned2014-10-16T08:30:54Z
dc.date.available2014-10-16T08:30:54Z
dc.date.issued2013
dc.identifier.citationFeng, S., Song, L., Liu, Y., Lai, F., Zuo, G., He, G., Chen, M., Huang, D. (2013). Hypoglycemic activities of commonly-used traditional Chinese herbs. American Journal of Chinese Medicine 41 (4) : 849-864. ScholarBank@NUS Repository. https://doi.org/10.1142/S0192415X13500572
dc.identifier.issn0192415X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/93999
dc.description.abstractThe α-amylase and α-glucosidase inhibition activity of 92 Traditional Chinese Medicinal (TCM) herbs, which are permitted to be used as food ingredients, were evaluated using the high throughput assay developed in our laboratory. Among these herbs, twenty-seven of them possessed significant α-amylase inhibition activities ranging from 2.4 to 349.2 μmol AE/g (AE = acarbose equivalent) with inhibition concentrations at 50% inhibition (IC50) from 16.0 to 2342.2 μg/mL, respectively. In addition, they showed α-glucosidase inhibition activities ranging from 0.5 to 31.6 μmolAE/g (IC50 from 49.0 to 3385.5 μg/mL). The extracts of Rhizoma fagopyri dibotryis (Jīnqiáomài), Rosa rugosa (Méiguīhuā), Caulis polygoni multiflori (Shuwūté ng), Fructus amomi (Shārén), Rhizoma alpiniae officinarum (Gāoliángjiāng), Folium ginkgo (Yínxì ngyè) and Cortex cinnamomi (Ròuguì) showed the better inhibitory activities against both α-amylase and α-glucosidase. Our results illustrated that these food grade herbs are potent natural hypoglycemic agents and can be used as active ingredients for low glycemic index food production or TCM herbal formulations for controlling hyperglycemia. © 2013 World Scientific Publishing Company Institute for Advanced Research in Asian Science and Medicine.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1142/S0192415X13500572
dc.sourceScopus
dc.subjectα-Amylase
dc.subjectα-Glucosidase
dc.subjectDiabetes
dc.subjectHerbal Medicine
dc.subjectHigh Throughput Screen
dc.subjectStarch Hydrolysis
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1142/S0192415X13500572
dc.description.sourcetitleAmerican Journal of Chinese Medicine
dc.description.volume41
dc.description.issue4
dc.description.page849-864
dc.description.codenAJCMB
dc.identifier.isiut000322444500009
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