Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol9023419
Title: High-throughput discovery of mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry
Authors: Tan, L.P. 
Wu, H. 
Yang, P.-Y.
Kalesh, K.A.
Zhang, X.
Hu, M.
Srinivasan, R.
Yao, S.Q. 
Issue Date: 2009
Citation: Tan, L.P., Wu, H., Yang, P.-Y., Kalesh, K.A., Zhang, X., Hu, M., Srinivasan, R., Yao, S.Q. (2009). High-throughput discovery of mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry. Organic Letters 11 (22) : 5102-5105. ScholarBank@NUS Repository. https://doi.org/10.1021/ol9023419
Abstract: A ∼500-member library of bidentate inhibitors against protein tyrosine phosphatases (PTPs) was rapidly assembled using click chemistry. Subsequent high-throughput screening had led to the discovery of highly potent (K i as low as 150 nM) and selective MptpB inhibitors, some of which represent the most potent MptpB inhibitors developed to date. © 2009 American Chemical society.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/93960
ISSN: 15237060
DOI: 10.1021/ol9023419
Appears in Collections:Staff Publications

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