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|Title:||High-throughput discovery of mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry||Authors:||Tan, L.P.
|Issue Date:||2009||Citation:||Tan, L.P., Wu, H., Yang, P.-Y., Kalesh, K.A., Zhang, X., Hu, M., Srinivasan, R., Yao, S.Q. (2009). High-throughput discovery of mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry. Organic Letters 11 (22) : 5102-5105. ScholarBank@NUS Repository. https://doi.org/10.1021/ol9023419||Abstract:||A ∼500-member library of bidentate inhibitors against protein tyrosine phosphatases (PTPs) was rapidly assembled using click chemistry. Subsequent high-throughput screening had led to the discovery of highly potent (K i as low as 150 nM) and selective MptpB inhibitors, some of which represent the most potent MptpB inhibitors developed to date. © 2009 American Chemical society.||Source Title:||Organic Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/93960||ISSN:||15237060||DOI:||10.1021/ol9023419|
|Appears in Collections:||Staff Publications|
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