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|Title:||Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detectionof DNA||Authors:||Shen, W.
|Issue Date:||12-Sep-2012||Citation:||Shen, W., Deng, H., Gao, Z. (2012-09-12). Gold nanoparticle-enabled real-time ligation chain reaction for ultrasensitive detectionof DNA. Journal of the American Chemical Society 134 (36) : 14678-14681. ScholarBank@NUS Repository.||Abstract:||A simple and ultrasensitive colorimetric DNA assay based on the detection of the product of a ligation chain reaction (LCR) and the use of gold nanoparticles (AuNPs) as signal generators has been developed. During LCR, the AuNPs were ligated together, resulting in a distinct color change in real time after a sufficient number of thermal cycles. The cumulative nature of the protocol produced a detection limit of 20 aM with a selectivity factor of 103. © 2012 American Chemical Society.||Source Title:||Journal of the American Chemical Society||URI:||http://scholarbank.nus.edu.sg/handle/10635/93894||ISSN:||00027863|
|Appears in Collections:||Staff Publications|
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