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Title: Discovery of a structural-element specific g-quadruplex "light-up" probe
Authors: Zhang, L.
Er, J.C.
Ghosh, K.K.
Chung, W.J.
Yoo, J.
Xu, W.
Zhao, W.
Phan, A.T.
Chang, Y.-T. 
Issue Date: 20-Jan-2014
Citation: Zhang, L., Er, J.C., Ghosh, K.K., Chung, W.J., Yoo, J., Xu, W., Zhao, W., Phan, A.T., Chang, Y.-T. (2014-01-20). Discovery of a structural-element specific g-quadruplex "light-up" probe. Scientific Reports 4 : -. ScholarBank@NUS Repository.
Abstract: The development of a fluorescent probe capable of detecting and distinguishing the wide diversity of G-quadruplex structures is particularly challenging. Herein, we report a novel BODIPY-based fluorescent sensor (GQR) that shows unprecedented selectivity to parallel-stranded G-quadruplexes with exposed ends and four medium grooves. Mechanistic studies suggest that GQR associates with G-quadruplex grooves close to the end of the tetrad core, which may explain the dye's specificity to only a subset of parallel structures. This specific recognition favours the disaggregation of GQR in aqueous solutions thereby recovering the inherent fluorescence of the dye. Due to its unique features, GQR represents a valuable tool for basic biological research and the rapid discovery of novel, specific ligands that target similar structural features of G-quadruplexes.
Source Title: Scientific Reports
ISSN: 20452322
DOI: 10.1038/srep03776
Appears in Collections:Staff Publications

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