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Title: Complexes of platinum(II) or palladium(II) with 1,10-phenanthroline and amino acids
Authors: Jin, V.X.
Ranford, J.D. 
Keywords: Amino acid complexes
Palladium complexes
Phenanthroline complexes
Platinum complexes
Issue Date: 15-Jun-2000
Citation: Jin, V.X., Ranford, J.D. (2000-06-15). Complexes of platinum(II) or palladium(II) with 1,10-phenanthroline and amino acids. Inorganica Chimica Acta 304 (1) : 38-44. ScholarBank@NUS Repository.
Abstract: The amino acids complexes of [Pt(phen)(AA)]NO3·xH2O and [Pd(phen)(AA)]NO3·xH2O have been prepared by the interaction of palladium and platinum complexes, [Pt(phen)Cl2] and [Pd(phen)Cl2] with salts of amino acids in methanol and characterized by 1H NMR and IR spectroscopy which confirmed the formation of a very large variety of compounds with ligand in a simple way (bidentate). All of these new compounds have been isolated and tested for cytotoxicity on Molt-4, a human leukaemia cell line. The IC50 values of [Pt(phen)(Pro)]Cl·2H2O and [Pd(phen)(Asp)]Cl·1.5H2O are 9.8 and 7.31 μM, respectively, exhibiting a significant activity which is close to cis-[PtCl2(NH3)2]. (C) 2000 Elsevier Science S.A.
Source Title: Inorganica Chimica Acta
ISSN: 00201693
DOI: 10.1016/S0020-1693(00)00061-X
Appears in Collections:Staff Publications

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