Please use this identifier to cite or link to this item:
|Title:||Characterization of the Anti-Diabetic and Antioxidant Effects of Rehmannia Glutinosa in Streptozotocin-Induced Diabetic Wistar Rats||Authors:||Waisundara, V.Y.
Traditional Chinese Medicine
|Issue Date:||2008||Citation:||Waisundara, V.Y., Huang, M., Hsu, A., Huang, D., Tan, B.K.-H. (2008). Characterization of the Anti-Diabetic and Antioxidant Effects of Rehmannia Glutinosa in Streptozotocin-Induced Diabetic Wistar Rats. American Journal of Chinese Medicine 36 (6) : 1083-1104. ScholarBank@NUS Repository. https://doi.org/10.1142/S0192415X08006594||Abstract:||This study investigated the effects of Rehmannia glutinosa individually as well as in combination with the oral hypoglycemic agent, metformin in streptozotocin (STZ)-induced diabetic Wistar rats. R. glutinosa ethanolic extract was prepared and the constituents were characterized using fractionation by column chromatography, followed by high performance liquid chromatography-mass spectrometry. STZ (65 mg/kg) was injected intraperitoneally to induce diabetes in Wistar rats. The diabetic rats were divided into the following groups (each n = 6) and received the respective treatments for 30 days: (1) metformin (500 mg/kg), (2) R. glutinosa (200 mg/kg), (3) metformin (500 mg/kg) and R. glutinosa (200 mg/kg) and (4) diabetic control (DC). A reduction in plasma glucose levels caused by the herb was not as significant as metformin compared to the diabetic control (p < 0.05). However, R. glutinosa -treated group showed reductions in plasma C-reactive protein (CRP) levels compared to the diabetic controls (p < 0.05) as well as metformin-treated group (p < 0.05). An enhanced reduction in CRP concentration was observed in the group receiving both herb and metformin compared to metformin-treated group (p < 0.05). Reduction in CRP levels suggests an anti-inflammatory activity of the herb. © 2008 World Scientific Publishing Company.||Source Title:||American Journal of Chinese Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/93270||ISSN:||0192415X||DOI:||10.1142/S0192415X08006594|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 16, 2019
WEB OF SCIENCETM
checked on Sep 16, 2019
checked on Sep 21, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.