Please use this identifier to cite or link to this item:
Title: Biosynthesis of mangostin. Part 1: The origin of the xanthone skeleton
Authors: Bennett, G.J. 
Lee, H.-H. 
Das, N.P.
Issue Date: 1990
Citation: Bennett, G.J.,Lee, H.-H.,Das, N.P. (1990). Biosynthesis of mangostin. Part 1: The origin of the xanthone skeleton. Journal of the Chemical Society, Perkin Transactions 1 (10) : 2671-2676. ScholarBank@NUS Repository.
Abstract: The biosynthesis of mangostin (3) has been studied by wick-feeding of 14C- and 13C-labelled precursors to young Garcinia mangostana plants. Radioactive mangostin was isolated as 3,6-di-O- methylmangostin (4), which was subsequently degraded to phloroglucinol and isovaleric acid to aid location of the label. Although results from feeding of 14C-labelled precursors suggested two alternative malonate-shikimate routes to compound (3), experiments with 13C-labelled compounds clearly demonstrated that mangostin (3) originates from a C6C 1 unit (benzoate) and three C2 units (malonates). [1,2,3-13C3]malonic acid was incorporated solely into ring A of compound (4) and two different arrangements of C2 units in compounds (17a and b) were evident, indicating that mangostin (3) derives via ring closure of a symmetrical intermediate (18).
Source Title: Journal of the Chemical Society, Perkin Transactions 1
ISSN: 14727781
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

checked on Oct 11, 2020

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.