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Title: "click" synthesis of small-molecule inhibitors targeting caspases
Authors: Ng, S.L.
Yang, P.-Y.
Chen, K.Y.-T. 
Srinivasan, R.
Yao, S.Q. 
Issue Date: 2008
Citation: Ng, S.L., Yang, P.-Y., Chen, K.Y.-T., Srinivasan, R., Yao, S.Q. (2008). "click" synthesis of small-molecule inhibitors targeting caspases. Organic and Biomolecular Chemistry 6 (5) : 844-847. ScholarBank@NUS Repository.
Abstract: A panel of 198 P4-diversified aldehyde (reversible) and vinyl sulfone (irreversible) inhibitors is successfully synthesized via an efficient "click chemistry" platform and directly screened against caspase-3 and -7 for inhibition. © The Royal Society of Chemistry.
Source Title: Organic and Biomolecular Chemistry
ISSN: 14770520
DOI: 10.1039/b718304f
Appears in Collections:Staff Publications

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