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|Title:||The influence of anionic chitin derivatives on calcium phosphate crystallization||Authors:||Wan Andrew, C.A.
|Keywords:||Anionic chitin derivatives
|Issue Date:||Jul-1998||Citation:||Wan Andrew, C.A., Khor, E., Hastings, G.W. (1998-07). The influence of anionic chitin derivatives on calcium phosphate crystallization. Biomaterials 19 (14) : 1309-1316. ScholarBank@NUS Repository. https://doi.org/10.1016/S0142-9612(98)00046-5||Abstract:||The influence of two water-soluble anionic chitin derivatives, sodium carboxymethyl-chitin (CM-chitin) and phosphoryl-chitin (P-chitin) on the crystallization of calcium phosphate by seeded growth and turbidimetry were studied. The adsorption of these derivatives onto hydroxyapatite obtained at 37°C, fitted the Langmuir isotherm. The affinity constant and number of adsorption sites were measured at 2.9 and 1.69 μmol m-2 for CM-chitin and 11.85 and 4.23 μmol m-2 for P-chitin. P-chitin exerted a potent inhibitory effect on the seeded growth of hydroxyapatite from a supersaturated solution, reducing the initial rate of crystallization by more than 90% at a solution concentration of 10-4 M. Both chitin derivatives also retarded the rate of spontaneous calcium phosphate precipitation. The type of calcium phosphate precipitated was poorly crystallized, calcium-deficient apatite. The chitin derivatives were found to be incorporated into the precipitate and influenced both the phase and morphology of calcium phosphate formed.||Source Title:||Biomaterials||URI:||http://scholarbank.nus.edu.sg/handle/10635/92800||ISSN:||01429612||DOI:||10.1016/S0142-9612(98)00046-5|
|Appears in Collections:||Staff Publications|
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