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Title: Atropine for the Treatment of Childhood Myopia: Effect on Myopia Progression after Cessation of Atropine
Authors: Tong, L.
Huang, X.L.
Koh, A.L.T.
Zhang, X.
Tan, D.T.H. 
Chua, W.-H.
Issue Date: Mar-2009
Citation: Tong, L., Huang, X.L., Koh, A.L.T., Zhang, X., Tan, D.T.H., Chua, W.-H. (2009-03). Atropine for the Treatment of Childhood Myopia: Effect on Myopia Progression after Cessation of Atropine. Ophthalmology 116 (3) : 572-579. ScholarBank@NUS Repository.
Abstract: Purpose: The aim of this study was to assess the effect on myopia progression after cessation of topical atropine treatment. Design: Parallel-group, placebo-controlled, randomized, double-masked study. Participants: Four hundred children aged 6 to 12 years with refractive error of spherical equivalent -1.00 to -6.00 diopters (D) and astigmatism of -1.50 D or less. Intervention: No intervention was administered. Subjects were followed up for 12 months after stopping treatment, which consisted of either 1% atropine or vehicle eyedrops once nightly for 2 years. Only 1 eye of each subject was chosen through randomization for treatment. Main Outcome Measures: The main efficacy outcome measures were change in spherical equivalent refraction as measured by cycloplegic autorefraction and change in ocular axial length as measured by ultrasonography. Results: After cessation of atropine drops, the mean progression in the atropine-treated group was -1.14±0.80 D over 1 year, whereas the progression in placebo-treated eyes was -0.38±0.39 D (P<0.0001). However, after 3 years of participation in the trial (with 2 years on atropine treatment), eyes randomized to atropine have less severe myopia than other eyes. Spherical equivalent was -4.29±1.67 D in the atropine-treated eyes compared with -5.22±1.38 D in the placebo-treated eyes (P<0.0001). Spherical equivalents in atropine-untreated and placebo-untreated eyes were -5.00±1.62 D and -5.28±1.43 D, respectively. Over the 3 years, the increase in axial length of the atropine-treated eyes was 0.29±0.37 mm compared with 0.52±0.45 mm in the placebo-treated eyes (P<0.0001). After cessation of atropine, the amplitude of accommodation and near visual acuity returned to pretreatment levels. Conclusions: After stopping treatment, eyes treated with atropine demonstrated higher rates of myopia progression compared with eyes treated with placebo. However, the absolute myopia progression after 3 years was significantly lower in the atropine group compared with placebo. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. © 2009 American Academy of Ophthalmology.
Source Title: Ophthalmology
ISSN: 01616420
DOI: 10.1016/j.ophtha.2008.10.020
Appears in Collections:Staff Publications

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