Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1385-8947(97)00121-6
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dc.titleKinetic and equilibrium study of the separation of propranolol enantiomers by high performance liquid chromatography on a chiral adsorbent
dc.contributor.authorDuan, G.
dc.contributor.authorChing, C.B.
dc.contributor.authorSwarup, S.
dc.date.accessioned2014-10-09T08:19:09Z
dc.date.available2014-10-09T08:19:09Z
dc.date.issued1998-03
dc.identifier.citationDuan, G., Ching, C.B., Swarup, S. (1998-03). Kinetic and equilibrium study of the separation of propranolol enantiomers by high performance liquid chromatography on a chiral adsorbent. Chemical Engineering Journal 69 (2) : 111-117. ScholarBank@NUS Repository. https://doi.org/10.1016/S1385-8947(97)00121-6
dc.identifier.issn13858947
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/91528
dc.description.abstractThe kinetic and equilibrium constants for the chromatographic enantioseparation of racemic propranolol, using cellulose tri(3,5-dimethyl-phenylcarbamate) as the chiral stationary phase and hexane and isopropanol as the mobile phase, were evaluated by moment analysis on the basis of equilibrium-dispersive and linear driving force models. The overall mass transfer coefficients were evaluated to be 0.56 s-1 and 1.08 s-1 for the S-(-) and R-(+) enantiomers of propranolol. Other system properties, required as input parameters for the modelling and simulation of the process under consideration, including the voidage of the column and the axial dispersion coefficient, were also determined. The parameters obtained were used to simulate the two single enantiomer band profiles at different flow rates. The simulated results were found to match the experimental results quite well. These parameters are very important for the design of preparative chromatography.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S1385-8947(97)00121-6
dc.sourceScopus
dc.subjectEquilibrium
dc.subjectHigh performance liquid chromatography
dc.subjectKinetic
dc.subjectPropranolol enantiomers
dc.typeArticle
dc.contributor.departmentCHEMICAL ENGINEERING
dc.description.doi10.1016/S1385-8947(97)00121-6
dc.description.sourcetitleChemical Engineering Journal
dc.description.volume69
dc.description.issue2
dc.description.page111-117
dc.description.codenCMEJA
dc.identifier.isiut000072911500005
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