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Title: Toxicological evaluation of microcystins in aquatic fish species: Current knowledge and future directions
Authors: Pavagadhi, S.
Balasubramanian, R. 
Keywords: Biomonitoring
Cyanobacterial blooms
Issue Date: 5-Oct-2013
Citation: Pavagadhi, S., Balasubramanian, R. (2013-10-05). Toxicological evaluation of microcystins in aquatic fish species: Current knowledge and future directions. Aquatic Toxicology 142-143 : 1-16. ScholarBank@NUS Repository.
Abstract: Microcystins (MCs) are algal toxins produced intracellularly within the algal cells, and are subsequently released into the aquatic systems. An increase in the frequency and intensity of occurrence of harmful algal blooms has directed the global attention towards the presence of MCs in aquatic systems. The effects of MCs on fish have been verified in a number of studies including histological, biochemical and behavioral effects. The toxicological effects of MCs on different organs of fish are related to the exposure route (intraperitoneal injection, feeding or immersion), the mode of uptake (passive or active transport) as well as biotransformation and bioaccumulation capabilities by different organs. This paper reviews the rapidly expanding literature on the toxicological evaluation of MCs in fish from both field studies and controlled laboratory experimental investigations, integrates the current knowledge available about the mechanisms involved in MC-induced effects on fish, and points out future research directions from a cross-disciplinary perspective. In addition, the need to carry out systematic fish toxicity studies to account for possible interactions between MCs and other environmental pollutants in aquatic systems is discussed. © 2013 Elsevier B.V.
Source Title: Aquatic Toxicology
ISSN: 0166445X
DOI: 10.1016/j.aquatox.2013.07.010
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