Please use this identifier to cite or link to this item:
|Title:||Mechanoregulation of stem cell fate via micro-/nano-scale manipulation for regenerative medicine||Authors:||Tay, C.Y.
stem cell biology
stem cell differentiation
|Issue Date:||Apr-2013||Citation:||Tay, C.Y., Koh, C.G., Tan, N.S., Leong, D.T., Tan, L.P. (2013-04). Mechanoregulation of stem cell fate via micro-/nano-scale manipulation for regenerative medicine. Nanomedicine 8 (4) : 623-638. ScholarBank@NUS Repository. https://doi.org/10.2217/nnm.13.31||Abstract:||Recent developments in the field of mechanobiology have renewed the call for a better understanding of the role of mechanical forces as potent regulators and indicators of stem cell fate. Although it is well established that mechanical forces play a crucial role in guiding tissue development, little is known about how submicroscopic biomechanical forces can influence key stem cell behaviors. This review will detail the use of micro-/nano-technologies that are advancing our current understanding of stem cell mechanobiology, and mechanoregulation of stem cell fate using engineered surface topographies and small-scale patterning techniques. The involvement of focal adhesions and the cytoskeleton systems as a common biophysical impetus through which these mechanical signals are transduced via distinct signaling pathways will also be discussed. These insights are envisioned to provide the basis for the rational design of future biocompatible materials and may inspire alternative drug-free therapeutic strategies to manage diseased sites via biomechanical management. © 2013 Future Medicine Ltd.||Source Title:||Nanomedicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/90847||ISSN:||17435889||DOI:||10.2217/nnm.13.31|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 10, 2019
WEB OF SCIENCETM
checked on Oct 3, 2019
checked on Oct 12, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.