Please use this identifier to cite or link to this item: https://doi.org/10.1258/ebm.2010.010021
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dc.titleNanoparticle-induced pulmonary toxicity
dc.contributor.authorLi, J.J.
dc.contributor.authorMuralikrishnan, S.
dc.contributor.authorNg, C.-T.
dc.contributor.authorYung, L.-Y.L.
dc.contributor.authorBay, B.-H.
dc.date.accessioned2014-10-09T07:09:18Z
dc.date.available2014-10-09T07:09:18Z
dc.date.issued2010-09
dc.identifier.citationLi, J.J., Muralikrishnan, S., Ng, C.-T., Yung, L.-Y.L., Bay, B.-H. (2010-09). Nanoparticle-induced pulmonary toxicity. Experimental Biology and Medicine 235 (9) : 1025-1033. ScholarBank@NUS Repository. https://doi.org/10.1258/ebm.2010.010021
dc.identifier.issn15353702
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/90807
dc.description.abstractIn recent decades, advances in nanotechnology engineering have given rise to the rapid development of many novel applications in the biomedical field. However, studies into the health and safety of these nanomaterials are still lacking. The main concerns are the adverse effects to health caused by acute or chronic exposure to nanoparticles (NPs), especially in the workplace environment. The lung is one of the main routes of entry for NPs into the body and, hence, a likely site for accumulation of NPs. Once NPs enter the interstitial air spaces and are quickly taken up by alveolar cells, they are likely to induce toxic effects. In this review, we highlight the different aspects of lung toxicity resulting from NP exposure, such as generation of oxidative stress, DNA damage and inflammation leading to fibrosis and pneumoconiosis, and the underlying mechanisms causing pulmonary toxicity. Copyright © 2010 by the Society for Experimental Biology and Medicine.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1258/ebm.2010.010021
dc.sourceScopus
dc.subjectLung injury
dc.subjectNanoparticles
dc.subjectNanotoxicity
dc.subjectOxidative stress
dc.subjectParticulate matter
dc.subjectPulmonary fibrosis
dc.typeOthers
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1258/ebm.2010.010021
dc.description.sourcetitleExperimental Biology and Medicine
dc.description.volume235
dc.description.issue9
dc.description.page1025-1033
dc.description.codenEBMMB
dc.identifier.isiut000281917900002
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