Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.2023312
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dc.titleFar-red/near-infrared fluorescent bioprobes based on biocompatible nanoparticles with aggregation-induced emission characteristics for bioimaging applications
dc.contributor.authorQin, W.
dc.contributor.authorDing, D.
dc.contributor.authorLiu, B.
dc.contributor.authorTang, B.Z.
dc.date.accessioned2014-10-09T07:06:29Z
dc.date.available2014-10-09T07:06:29Z
dc.date.issued2013
dc.identifier.citationQin, W., Ding, D., Liu, B., Tang, B.Z. (2013). Far-red/near-infrared fluorescent bioprobes based on biocompatible nanoparticles with aggregation-induced emission characteristics for bioimaging applications. Proceedings of SPIE - The International Society for Optical Engineering 8831 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.2023312
dc.identifier.isbn9780819496812
dc.identifier.issn0277786X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/90544
dc.description.abstractLight emission of 2-(2,6-bis((E)-4-(diphenylamino)styryl]-4H-pyran-4- ylidene}malononitrile (TPA-DCM) is weakened by aggregate formation. Attaching tetraphenylethene (TPE) units as terminals to TPA-DCM dramatically changes its emission behavior: the resulting fluorogen 2-(2,6-bis((E)-4-(phenyl(4′-(1, 2,2-triphenylvinyl)-[1,1′-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene) malononitrile (TPE-TPA-DCM) is more emissive in the aggregate state, showing a novel phenomenon of aggregation-induced emission (AIE). Formulation of TPE-TPA-DCM using bovine serum albumin (BSA) as the polymer matrix yields uniformly sized protein nanoparticles (NPs) with high brightness and low cytotoxicity. Applications of the fluorogen-loaded BSA NPs for in vitro and in vivo far-red/near-infrared (FR/NIR) bioimaging are successfully demonstrated using MCF-7 breast cancer cells and a murine hepatoma-22 (H22) tumor-bearing mice model, respectively. The AIE-active fluorogen-loaded BSA NPs show excellent cancer cell uptake and prominent tumor targeting ability in vivo due to the enhanced permeability and retention effect. © 2013 SPIE.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/12.2023312
dc.sourceScopus
dc.subjectAggregation-induced emission
dc.subjectFluorescence bioimaging
dc.subjectNanoparticles
dc.subjectRed light emission
dc.subjectTetraphenylethene
dc.typeConference Paper
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1117/12.2023312
dc.description.sourcetitleProceedings of SPIE - The International Society for Optical Engineering
dc.description.volume8831
dc.description.page-
dc.description.codenPSISD
dc.identifier.isiut000327122500011
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