Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.2023312
Title: Far-red/near-infrared fluorescent bioprobes based on biocompatible nanoparticles with aggregation-induced emission characteristics for bioimaging applications
Authors: Qin, W.
Ding, D. 
Liu, B. 
Tang, B.Z.
Keywords: Aggregation-induced emission
Fluorescence bioimaging
Nanoparticles
Red light emission
Tetraphenylethene
Issue Date: 2013
Citation: Qin, W., Ding, D., Liu, B., Tang, B.Z. (2013). Far-red/near-infrared fluorescent bioprobes based on biocompatible nanoparticles with aggregation-induced emission characteristics for bioimaging applications. Proceedings of SPIE - The International Society for Optical Engineering 8831 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.2023312
Abstract: Light emission of 2-(2,6-bis((E)-4-(diphenylamino)styryl]-4H-pyran-4- ylidene}malononitrile (TPA-DCM) is weakened by aggregate formation. Attaching tetraphenylethene (TPE) units as terminals to TPA-DCM dramatically changes its emission behavior: the resulting fluorogen 2-(2,6-bis((E)-4-(phenyl(4′-(1, 2,2-triphenylvinyl)-[1,1′-biphenyl]-4-yl)amino)styryl)-4H-pyran-4-ylidene) malononitrile (TPE-TPA-DCM) is more emissive in the aggregate state, showing a novel phenomenon of aggregation-induced emission (AIE). Formulation of TPE-TPA-DCM using bovine serum albumin (BSA) as the polymer matrix yields uniformly sized protein nanoparticles (NPs) with high brightness and low cytotoxicity. Applications of the fluorogen-loaded BSA NPs for in vitro and in vivo far-red/near-infrared (FR/NIR) bioimaging are successfully demonstrated using MCF-7 breast cancer cells and a murine hepatoma-22 (H22) tumor-bearing mice model, respectively. The AIE-active fluorogen-loaded BSA NPs show excellent cancer cell uptake and prominent tumor targeting ability in vivo due to the enhanced permeability and retention effect. © 2013 SPIE.
Source Title: Proceedings of SPIE - The International Society for Optical Engineering
URI: http://scholarbank.nus.edu.sg/handle/10635/90544
ISBN: 9780819496812
ISSN: 0277786X
DOI: 10.1117/12.2023312
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