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Title: Supercritical antisolvent production of biodegradable micro- and nanoparticles for controlled delivery of paclitaxel
Authors: Lee, L.Y.
Wang, C.H. 
Smith, K.A.
Keywords: Biodegradable nanoparticles
Enhanced mixing
Supercritical antisolvent
Issue Date: 22-Jan-2008
Citation: Lee, L.Y., Wang, C.H., Smith, K.A. (2008-01-22). Supercritical antisolvent production of biodegradable micro- and nanoparticles for controlled delivery of paclitaxel. Journal of Controlled Release 125 (2) : 96-106. ScholarBank@NUS Repository.
Abstract: Paclitaxel and poly (l-Lactic acid) (PLA) were co-precipitated to form micro and submicron particles in a manner similar to that used in the supercritical antisolvent with enhanced mass transfer (SAS-EM) process. As compared with conventional processes, a major advantage of supercritical CO2 as an antisolvent in the SAS-EM process is the effective removal of residual organic solvents. In this work, the organic phase was sprayed into supercritical CO2 (for CO2, Tc = 31.1 °C, Pc = 73.8 bar) from a 500 μm ID capillary nozzle. Ultrasonic vibration with an amplitude of 0 to 120 μm (from a 3/8″ tip diameter titanium probe) was employed in the high pressure vessel during the antisolvent process to provide enhanced mixing between the solvent and antisolvent phases. The role and effects of ultrasonication on the properties of the resulting particles were studied. When no ultrasonication was applied, micrometer-sized particles were obtained. When ultrasonication was applied, more uniform particles in the submicron size range were obtained. The size of the particles was found to vary with the ultrasonic vibration amplitude. Encapsulation efficiencies up to 83.5% and controlled release of paclitaxel for more than 30 days were achieved with the particles fabricated in this study. © 2007 Elsevier B.V. All rights reserved.
Source Title: Journal of Controlled Release
ISSN: 01683659
DOI: 10.1016/j.jconrel.2007.10.002
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