Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/90129
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dc.titleSensitivity measures for oscillating systems: Application to mammalian circadian gene network
dc.contributor.authorTaylor, S.R.
dc.contributor.authorGunawan, R.
dc.contributor.authorPetzold, L.R.
dc.contributor.authorDoyle III, F.J.
dc.date.accessioned2014-10-09T07:01:42Z
dc.date.available2014-10-09T07:01:42Z
dc.date.issued2008-01
dc.identifier.citationTaylor, S.R., Gunawan, R., Petzold, L.R., Doyle III, F.J. (2008-01). Sensitivity measures for oscillating systems: Application to mammalian circadian gene network. IEEE Transactions on Automatic Control 53 (SPECIAL ISSUE) : 177-188. ScholarBank@NUS Repository.
dc.identifier.issn00189286
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/90129
dc.description.abstractVital physiological behaviors exhibited daily by bacteria, plants, and animals are governed by endogenous oscillators called circadian clocks. The most salient feature of the circadian clock is its ability to change its internal time (phase) to match that of the external environment. The circadian clock, like many oscillators in nature, is regulated at the cellular level by a complex network of interacting components. As a complementary approach to traditional biological investigation, we utilize mathematical models and systems-theoretic tools to elucidate these mechanisms. The models are systems of ordinary differential equations exhibiting stable limit cycle behavior. To study the robustness of circadian phase behavior, we use sensitivity analysis. As the standard set of sensitivity tools are not suitable for the study of phase behavior, we introduce a novel tool, the parametric impulse phase response curve. © 2008 IEEE.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1109/TAC.2007.911364
dc.sourceScopus
dc.subjectBiological clock
dc.subjectPhase response curve
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.sourcetitleIEEE Transactions on Automatic Control
dc.description.volume53
dc.description.issueSPECIAL ISSUE
dc.description.page177-188
dc.description.codenIETAA
dc.identifier.isiut000253158000018
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