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|Title:||Polymer microspheres with permanent antibacterial surface from surface-initiated atom transfer radical polymerization of 4-vinylpyridine and quaternization||Authors:||Cheng, Z.
|Issue Date:||Apr-2006||Citation:||Cheng, Z.,Zhu, X.,Shi, Z.L.,Neoh, K.G.,Kang, E.T. (2006-04). Polymer microspheres with permanent antibacterial surface from surface-initiated atom transfer radical polymerization of 4-vinylpyridine and quaternization. Surface Review and Letters 13 (2-3) : 313-318. ScholarBank@NUS Repository.||Abstract:||Crosslinked poly(4-vinylbenzyl chloride) (PVBC) microspheres of about 550pm in diameter were first synthesized by suspension copolymerization of 4-vinylbenzyl chloride (VBC) in the presence of a crosslinking agent, ethylene glycol dimethacrylate (EGDMA). Subsequent surfaceinitiated atom transfer radical polymerization (ATRP) of 4-vinylpyridine (4VP), using the VBC units of PVBC on the microsphere surface as the macroinitiators, produced well-defined (nearly monodisperse) and covalently tethered poly(4-vinylpyridine) (P4VP) brushes. Quaternization of the tertiary amine groups of the P4VP brushes with hexyl bromide gave rise to a high concentration of quaternary ammonium salt (QAS) on the microsphere surfaces. The chemical composition of the microsphere surfaces at various stages of surface modification was characterized by X-ray photoelectron spectroscopy (XPS). The bactericidal effect of the QAS-functionalized microspheres on Escherichia coli (E. coli) was demonstrated. No significant loss in the surface bactericidal activity of the microsphere was observed during repeated applications. © World Scientific Publishing Company.||Source Title:||Surface Review and Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/89848||ISSN:||0218625X|
|Appears in Collections:||Staff Publications|
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