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Title: PEGylated conjugated polyelectrolytes containing 2,1,3-benzoxadiazole units for targeted cell imaging
Authors: Liu, J.
Ding, D. 
Geng, J.
Liu, B. 
Issue Date: Jun-2012
Citation: Liu, J., Ding, D., Geng, J., Liu, B. (2012-06). PEGylated conjugated polyelectrolytes containing 2,1,3-benzoxadiazole units for targeted cell imaging. Polymer Chemistry 3 (6) : 1567-1575. ScholarBank@NUS Repository.
Abstract: Two amphiphilic conjugated polyelectrolytes (CPEs) were designed and synthesized via a post-polymerization strategy. A neutral precursor polymer of poly(9,9-bis(6′-azidohexyl)fluorene-alt-2,1,3-benzoxadiazole) (PFBD-N 3) was synthesized first through Suzuki polymerization, which was followed by click reaction to incorporate dense poly(ethylene glycol) (PEG) to afford PFBD-PEG 600-COOH and PFBD-PEG 2000-COOH, respectively. The CPEs show better solubility in water with increasing PEG chain length due to the increased hydrophilicity of longer PEG chains. Both CPEs formed nanoparticles (NPs) in water and were used as cellular probes for visualization of HT-29 cancer cells. As compared to PFBD-PEG 600-COOH NPs, PFBD-PEG 2000-COOH NPs were less efficiently taken up by cells due to the longer PEG side chains, which significantly inhibited nonspecific cellular uptake. Further conjugation of PFBD-PEG 2000-COOH with c(RGDfK) yielded PFBD-PEG 2000-RGD NPs as a specific cellular probe for targeted cancer cell imaging. Preliminary study revealed that PFBD-PEG 2000-RGD NPs were favorable for targeted cellular imaging with low cytotoxicity, high selectivity and good photostability. This journal is © The Royal Society of Chemistry 2012.
Source Title: Polymer Chemistry
ISSN: 17599954
DOI: 10.1039/c2py20113e
Appears in Collections:Staff Publications

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