Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/89714
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dc.titlePaclitaxel and suramin-loaded core/shell microspheres in the treatment of brain tumors
dc.contributor.authorNie, H.
dc.contributor.authorFu, Y.
dc.contributor.authorWang, C.-H.
dc.date.accessioned2014-10-09T06:56:57Z
dc.date.available2014-10-09T06:56:57Z
dc.date.issued2010-11
dc.identifier.citationNie, H., Fu, Y., Wang, C.-H. (2010-11). Paclitaxel and suramin-loaded core/shell microspheres in the treatment of brain tumors. Biomaterials 31 (33) : 8732-8740. ScholarBank@NUS Repository.
dc.identifier.issn01429612
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/89714
dc.description.abstractThis work presents a modified method, namely coaxial electrohydrodynamic atomization, for the preparation of microspheres with distinct core/shell structures. This allows the encapsulation of two drugs with different characteristics in hydrophilic properties in one single step. Variation of ratios between outer flow and inner flow produces polymer microspheres with different core/shell ratios, and consequently results in variable release rates of drugs. Significant changes in release patterns were demonstrated when the distributions of the two drugs in microspheres were swapped. Moreover, cell culture experiments and animal experiments have been carried out to testify the performances of different microspheres in cytotoxicity, cellular apoptosis in vitro and tumor inhibition against subcutaneous U87 glioma xenograft in BALB/c nude mice. These findings present the advantages and possible application of this kind of multi-drug release system in treating brain tumors. Moreover, the release rates and characteristic sequences of multi-drugs can be tailored and tuned according to treatment necessity and applied in treating other kinds of tumors. © 2010 Elsevier Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2010.07.080
dc.sourceScopus
dc.subjectChemotherapy
dc.subjectDrug delivery
dc.subjectIn vivo
dc.subjectMicrosphere
dc.subjectPaclitaxel
dc.subjectSuramin
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.sourcetitleBiomaterials
dc.description.volume31
dc.description.issue33
dc.description.page8732-8740
dc.description.codenBIMAD
dc.identifier.isiut000283912700025
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