Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.actbio.2013.11.012
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dc.titleMussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery
dc.contributor.authorJiang, J.
dc.contributor.authorXie, J.
dc.contributor.authorMa, B.
dc.contributor.authorBartlett, D.E.
dc.contributor.authorXu, A.
dc.contributor.authorWang, C.-H.
dc.date.accessioned2014-10-09T06:54:55Z
dc.date.available2014-10-09T06:54:55Z
dc.date.issued2014-03
dc.identifier.citationJiang, J., Xie, J., Ma, B., Bartlett, D.E., Xu, A., Wang, C.-H. (2014-03). Mussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery. Acta Biomaterialia 10 (3) : 1324-1332. ScholarBank@NUS Repository. https://doi.org/10.1016/j.actbio.2013.11.012
dc.identifier.issn17427061
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/89541
dc.description.abstractpH-responsive drug delivery systems could mediate drug releasing rate by changing the pH values at specific times as per the pathophysiological need of the disease. This paper demonstrates that a mussel-inspired protein polydopamine coating can tune the loading and releasing rate of charged molecules from electrospun poly(ε-caprolactone) (PCL) nanofibers in solutions with different pH values. In vitro release profiles show that the positive charged molecules release significantly faster in acidic than those in neutral and basic environments within the same incubation time. The results of fluorescein diacetate staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays show the viability of cancer cells after treatment with doxorubicin-released media at different pH values qualitatively and quantitatively, indicating that the media containing doxorubicin that were released in solutions at low pH values could kill a significantly higher number of cells than those released in solutions at high pH values. Together, the pH-responsive drug delivery systems based on polydopamine-coated PCL nanofibers could have potential application in the oral delivery of anticancer drugs for treating gastric cancer and in vaginal delivery of anti-viral drugs or anti-inflammatory drugs, which could raise their efficacy, deliver them to the specific target and minimize their toxic side effects. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.actbio.2013.11.012
dc.sourceScopus
dc.subjectDrug delivery
dc.subjectElectrospun fibers
dc.subjectpH sensitive
dc.subjectPoly(ε-caprolactone)
dc.subjectPolydopamine coating
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.actbio.2013.11.012
dc.description.sourcetitleActa Biomaterialia
dc.description.volume10
dc.description.issue3
dc.description.page1324-1332
dc.identifier.isiut000331663900026
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