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|Title:||Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery||Authors:||Shen, S.-C.
|Issue Date:||Oct-2011||Citation:||Shen, S.-C., Ng, W.K., Shi, Z., Chia, L., Neoh, K.G., Tan, R.B.H. (2011-10). Mesoporous silica nanoparticle-functionalized poly(methyl methacrylate)-based bone cement for effective antibiotics delivery. Journal of Materials Science: Materials in Medicine 22 (10) : 2283-2292. ScholarBank@NUS Repository. https://doi.org/10.1007/s10856-011-4397-1||Abstract:||Poly(methyl methacrylate)-based bone cements are functionalized with mesoporous silica nanoparticles (MSN) to enable a highly efficient and sustained release of antibiotics to reduce the risk of post-operative joint infection. To overcome the limited drug release of 5% for only 1 day with the current commercial-grade bone cements, a 8 wt% MSN-formulated bone cement is able to increase the drug release efficiency by 14-fold and sustain the release for up to 80 days. The loaded MSN is suggested to build up an effective network of rod-shaped silica particles with uniformly arranged nanoporous channels, which is responsible for the effective drug diffusion and extend time-release to the external surfaces. MSN has no detrimental effect on the critical weight-bearing bending modulus and compression strength of bone cement. In vitro assay test results show a much sustained antibacterial effect and low cytotoxicity of MSN demonstrating the potential applicability of MSN-formulated bone cement. © Springer Science+Business Media, LLC 2011.||Source Title:||Journal of Materials Science: Materials in Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/89385||ISSN:||09574530||DOI:||10.1007/s10856-011-4397-1|
|Appears in Collections:||Staff Publications|
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