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https://doi.org/10.1039/c0cc00735h
| Title: | Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution | Authors: | Tang, W.L. Li, Z. Zhao, H. |
Issue Date: | 14-Aug-2010 | Citation: | Tang, W.L., Li, Z., Zhao, H. (2010-08-14). Inverting the enantioselectivity of P450pyr monooxygenase by directed evolution. Chemical Communications 46 (30) : 5461-5463. ScholarBank@NUS Repository. https://doi.org/10.1039/c0cc00735h | Abstract: | We report the first example of directed evolution of a P450 monooxygenase with inverted enantioselectivity for asymmetric biohydroxylation. The biohydroxylation product of the best mutant 1AF4A has an ee of 83% (R) compared to the wild type's ee of 43% (S). © The Royal Society of Chemistry 2010. | Source Title: | Chemical Communications | URI: | http://scholarbank.nus.edu.sg/handle/10635/89278 | ISSN: | 13597345 | DOI: | 10.1039/c0cc00735h |
| Appears in Collections: | Staff Publications |
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