Please use this identifier to cite or link to this item: https://doi.org/10.1002/cmmi.373
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dc.titleBifunctional Eu3+-doped Gd2O3 nanoparticles as a luminescent and T1 contrast agent for stem cell labeling
dc.contributor.authorShi, Z.
dc.contributor.authorNeoh, K.G.
dc.contributor.authorKang, E.T.
dc.contributor.authorShuter, B.
dc.contributor.authorWang, S.-C.
dc.date.accessioned2014-10-09T06:43:52Z
dc.date.available2014-10-09T06:43:52Z
dc.date.issued2010-03
dc.identifier.citationShi, Z., Neoh, K.G., Kang, E.T., Shuter, B., Wang, S.-C. (2010-03). Bifunctional Eu3+-doped Gd2O3 nanoparticles as a luminescent and T1 contrast agent for stem cell labeling. Contrast Media and Molecular Imaging 5 (2) : 105-111. ScholarBank@NUS Repository. https://doi.org/10.1002/cmmi.373
dc.identifier.issn15554309
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88575
dc.description.abstractMagnetic resonance tracking of stem cells has recently become an emerging application for investigating cell-tissue interactions and guiding the development of effective stem cell therapies for regeneration of damaged tissues and organs. In this work, anionic Eu3+-doped Gd2O 3 hybrid nanoparticles were applied as a contrast agent both for fluorescence microscopy and T1-weighted MRI. The nanoparticles were synthesized through the polyol method and further modified with citric acid to obtain anionic nanoparticles. These nanoparticles were internalized into human mesenchymal stem cells (hMSCs) as confirmed by confocal laser scanning microscopy and quantified by inductively coupled plasma-mass spectrometry. MTT assay of the labeled cells showed that the nanoparticles did not possess significant cytotoxicity. In addition, the osteogenic, adipogenic and chondrogenic differentiation of the hMSCs was not influenced by the labeling process. With MRI, the in vitro detection threshold of cells after incubation with nanoparticles at a Gd concentration of 0.5mM for 2 h was estimated to be about 10 000 cells. The results from this study indicate that the biocompatible anionic Gd2O3 nanoparticles doped with Eu3+ show promise both as a luminescent and T1 contrast agent for use in visualizing hMSCs. Copyright © 2010 John Wiley & Sons, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/cmmi.373
dc.sourceScopus
dc.subjectContrast agent
dc.subjectGadolinium nanoparticles
dc.subjectMagnetic resonance imaging
dc.subjectStem cell labeling
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1002/cmmi.373
dc.description.sourcetitleContrast Media and Molecular Imaging
dc.description.volume5
dc.description.issue2
dc.description.page105-111
dc.identifier.isiut000277138600006
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