Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10439-011-0383-5
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dc.titleA regional blood flow model for β2-microglobulin kinetics and for simulating intra-dialytic exercise effect
dc.contributor.authorMaheshwari, V.
dc.contributor.authorSamavedham, L.
dc.contributor.authorRangaiah, G.P.
dc.date.accessioned2014-10-09T06:42:44Z
dc.date.available2014-10-09T06:42:44Z
dc.date.issued2011-12
dc.identifier.citationMaheshwari, V., Samavedham, L., Rangaiah, G.P. (2011-12). A regional blood flow model for β2-microglobulin kinetics and for simulating intra-dialytic exercise effect. Annals of Biomedical Engineering 39 (12) : 2879-2890. ScholarBank@NUS Repository. https://doi.org/10.1007/s10439-011-0383-5
dc.identifier.issn00906964
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88475
dc.description.abstractA kinetic model based on first principles, for β2- microglobulin, is presented to obtain precise parameter estimates for individual patient. To reduce the model complexity, the number of model parameters was reduced using a priori identifiability analysis. The model validity was confirmed with the clinical data of ten renal patients on post-dilution hemodiafiltration. The model fit resulted in toxin distribution volume (V d) of 14.22 ± 0.75 L, plasma fraction in extracellular compartment (fP) of 0.39 ± 0.03, and inter-compartmental clearance of 44 ± 4.1 mL min-1. Parameter estimates suggest that Vd and fP are much higher in hemodialysis patients than in normal subjects. The developed model predicts larger removed toxin mass than that predicted by the two-pool model. On the application front, the developed model was employed to explain the effect of intra-dialytic exercise on toxin removal. The presented simulations suggest that intra-dialytic exercise not only increases the blood flow to low flow region, but also decreases the inter-compartmental resistance. Combined, they lead to increased toxin removal during dialysis and reduced post-dialysis rebound. The developed model can assist in suggesting the improved dialysis dose based on β2- microglobulin, and also lead to quantitative inclusion of intra-dialytic exercise in the future. © 2011 Biomedical Engineering Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s10439-011-0383-5
dc.sourceScopus
dc.subjectA priori identifiability analysis
dc.subjectCardiac output
dc.subjectHemodiafiltration
dc.subjectInter-compartmental clearance
dc.subjectKinetic modeling
dc.subjectPlasma fraction
dc.subjectToxin distribution volume
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1007/s10439-011-0383-5
dc.description.sourcetitleAnnals of Biomedical Engineering
dc.description.volume39
dc.description.issue12
dc.description.page2879-2890
dc.description.codenABMEC
dc.identifier.isiut000296507000002
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