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Title: A novel dual-layer forward osmosis membrane for protein enrichment and concentration
Authors: Yang, Q. 
Wang, K.Y. 
Chung, T.-S. 
Keywords: Dewater
Dual-layer hollow fiber membrane
Forward osmosis
Protein enrichment
Issue Date: 15-Oct-2009
Citation: Yang, Q., Wang, K.Y., Chung, T.-S. (2009-10-15). A novel dual-layer forward osmosis membrane for protein enrichment and concentration. Separation and Purification Technology 69 (3) : 269-274. ScholarBank@NUS Repository.
Abstract: We have demonstrated the prospect of dual-layer polybenzimidazole-polyethersulfone/polyvinylpyrrolidone (PBI-PES/PVP) hollow fiber nanofiltration (NF) membranes in the forward osmosis (FO) process for the enrichment and concentration of pharmaceutical products without denaturing the component of interests. The dual-layer hollow fiber membrane via coextrusion technology has an ultra-thin selective skin around 10 μm, fully open-cell water channels underneath and a microporous sponge-like support structure. The self-charged PBI selective skin has an average pore radius at 0.4 nm with a sharp pore size distribution. Experimental results show that the newly developed dual-layer hollow fiber nanofiltration membrane can achieve a high throughput for lysozyme enrichment and less protein fouling when using it as a FO membrane. In addition, the high divalent salt rejection towards Mg2+ at around 90% of this dual-layer membrane ensures the enriched lysozyme product with high purity and without change and denaturing. © 2009 Elsevier B.V. All rights reserved.
Source Title: Separation and Purification Technology
ISSN: 13835866
DOI: 10.1016/j.seppur.2009.08.002
Appears in Collections:Staff Publications

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