Please use this identifier to cite or link to this item: https://doi.org/10.1039/c3nr02390g
DC FieldValue
dc.titleA general approach to prepare conjugated polymer dot embedded silica nanoparticles with a SiO2@CP@SiO2 structure for targeted HER2-positive cellular imaging
dc.contributor.authorGeng, J.
dc.contributor.authorLiu, J.
dc.contributor.authorLiang, J.
dc.contributor.authorShi, H.
dc.contributor.authorLiu, B.
dc.date.accessioned2014-10-09T06:42:24Z
dc.date.available2014-10-09T06:42:24Z
dc.date.issued2013-09-21
dc.identifier.citationGeng, J., Liu, J., Liang, J., Shi, H., Liu, B. (2013-09-21). A general approach to prepare conjugated polymer dot embedded silica nanoparticles with a SiO2@CP@SiO2 structure for targeted HER2-positive cellular imaging. Nanoscale 5 (18) : 8593-8601. ScholarBank@NUS Repository. https://doi.org/10.1039/c3nr02390g
dc.identifier.issn20403364
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88445
dc.description.abstractWe report on a one-step synthesis of conjugated polymer (CP) embedded silica nanoparticles (NPs) with a SiO2@CP@SiO2 structure by combination of a precipitation method and a modified Stöber approach. Four types of CPs are employed to demonstrate the versatility of the developed strategy, yielding fluorescent silica NPs with emission across the visible spectrum. Field emission transmission electron microscopy investigation reveals that the entanglement between hydrophobic CPs and the aminopropyl groups of 3-aminopropyl triethoxysilane contributes to the successful encapsulation of CPs into a silica matrix. The synthesized NPs exhibit excellent physical stability and good photostability. In addition, they have amine groups on surfaces, which benefit further conjugation for biological applications. Through reaction with a peptide (GGHAHFG) that is specific to the HER2 receptor, the synthesized NPs have been successfully applied for targeted cellular imaging of HER2-overexpressed SKBR-3 breast cancer cells. Along with its high quantum yield and benign biocompatibility, the developed CP embedded silica NPs have great potential for applications in biological imaging. © 2013 The Royal Society of Chemistry.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1039/c3nr02390g
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1039/c3nr02390g
dc.description.sourcetitleNanoscale
dc.description.volume5
dc.description.issue18
dc.description.page8593-8601
dc.identifier.isiut000323521000038
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.