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Title: Quantitative fiber-optic Raman spectroscopy for tissue Raman measurements
Authors: Duraipandian, S.
Bergholt, M. 
Zheng, W.
Huang, Z.
Keywords: Fiber-optic
In vivo
Raman spectroscopy
Issue Date: 2014
Citation: Duraipandian, S., Bergholt, M., Zheng, W., Huang, Z. (2014). Quantitative fiber-optic Raman spectroscopy for tissue Raman measurements. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8939 : -. ScholarBank@NUS Repository.
Abstract: Molecular profiling of tissue using near-infrared (NIR) Raman spectroscopy has shown great promise for in vivo detection and prognostication of cancer. The Raman spectra measured from the tissue generally contain fundamental information about the absolute biomolecular concentrations in tissue and its changes associated with disease transformation. However, producing analogues tissue Raman spectra present a great technical challenge. In this preliminary study, we propose a method to ensure the reproducible tissue Raman measurements and validated with the in vivo Raman spectra (n=150) of inner lip acquired using different laser powers (i.e., 30 and 60 mW). A rapid Raman spectroscopy system coupled with a ball-lens fiber-optic Raman probe was utilized for tissue Raman measurements. The investigational results showed that the variations between the spectra measured with different laser powers are almost negligible, facilitating the quantitative analysis of tissue Raman measurements in vivo. © 2014 SPIE.
Source Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISBN: 9780819498526
ISSN: 16057422
DOI: 10.1117/12.2039576
Appears in Collections:Staff Publications

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