Please use this identifier to cite or link to this item:
Title: Investigation of microstructural features in regenerating bone using micro computed tomography
Authors: Jones, A.C.
Sakellariou, A.
Limaye, A.
Arns, C.H.
Senden, T.J.
Sawkins, T.
Knackstedt, M.A.
Rohner, D.
Hutmacher, D.W. 
Brandwood, A.
Milthorpe, B.K.
Issue Date: Apr-2004
Citation: Jones, A.C., Sakellariou, A., Limaye, A., Arns, C.H., Senden, T.J., Sawkins, T., Knackstedt, M.A., Rohner, D., Hutmacher, D.W., Brandwood, A., Milthorpe, B.K. (2004-04). Investigation of microstructural features in regenerating bone using micro computed tomography. Journal of Materials Science: Materials in Medicine 15 (4) : 529-532. ScholarBank@NUS Repository.
Abstract: We illustrate some of the uses of micro-computed tomography (micro-CT) to study tissue-engineered bone using a micro-CT facility for imaging and visualizing biomaterials in three dimensions (3-D). The micro-CT is capable of acquiring 3D X-ray CT images made up of 20003 voxels on specimens up to 5 cm in extent with resolutions down to 2 μm. This allows the 3-D structure of tissue-engineered materials to be imaged across orders of magnitude in resolution. This capability is used to examine an explanted, tissue-engineered bone material based on a polycaprolactone scaffold and autologous bone marrow cells. Imaging of the tissue-engineered bone at a scale of 1 cm and resolutions of 10 μm allows one to visualize the complex ingrowth of bone into the polymer scaffold. From a theoretical viewpoint the voxel data may also be used to calculate expected mechanical properties of the tissue-engineered implant. These observations illustrate the benefits of tomography over traditional techniques for the characterization of bone morphology and interconnectivity. As the method is nondestructive it can perform a complimentary role to current histomorphometric techniques. © 2004 Kluwer Academic Publishers.
Source Title: Journal of Materials Science: Materials in Medicine
ISSN: 09574530
DOI: 10.1023/B:JMSM.0000021133.48661.62
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Apr 12, 2019


checked on Mar 20, 2019

Page view(s)

checked on Mar 2, 2019

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.