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|Title:||Investigation of microstructural features in regenerating bone using micro computed tomography||Authors:||Jones, A.C.
|Issue Date:||Apr-2004||Citation:||Jones, A.C., Sakellariou, A., Limaye, A., Arns, C.H., Senden, T.J., Sawkins, T., Knackstedt, M.A., Rohner, D., Hutmacher, D.W., Brandwood, A., Milthorpe, B.K. (2004-04). Investigation of microstructural features in regenerating bone using micro computed tomography. Journal of Materials Science: Materials in Medicine 15 (4) : 529-532. ScholarBank@NUS Repository. https://doi.org/10.1023/B:JMSM.0000021133.48661.62||Abstract:||We illustrate some of the uses of micro-computed tomography (micro-CT) to study tissue-engineered bone using a micro-CT facility for imaging and visualizing biomaterials in three dimensions (3-D). The micro-CT is capable of acquiring 3D X-ray CT images made up of 20003 voxels on specimens up to 5 cm in extent with resolutions down to 2 μm. This allows the 3-D structure of tissue-engineered materials to be imaged across orders of magnitude in resolution. This capability is used to examine an explanted, tissue-engineered bone material based on a polycaprolactone scaffold and autologous bone marrow cells. Imaging of the tissue-engineered bone at a scale of 1 cm and resolutions of 10 μm allows one to visualize the complex ingrowth of bone into the polymer scaffold. From a theoretical viewpoint the voxel data may also be used to calculate expected mechanical properties of the tissue-engineered implant. These observations illustrate the benefits of tomography over traditional techniques for the characterization of bone morphology and interconnectivity. As the method is nondestructive it can perform a complimentary role to current histomorphometric techniques. © 2004 Kluwer Academic Publishers.||Source Title:||Journal of Materials Science: Materials in Medicine||URI:||http://scholarbank.nus.edu.sg/handle/10635/88271||ISSN:||09574530||DOI:||10.1023/B:JMSM.0000021133.48661.62|
|Appears in Collections:||Staff Publications|
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