Please use this identifier to cite or link to this item:
https://doi.org/10.1007/978-3-540-92841-6_365
Title: | Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion | Authors: | Abbah, A.S. Lam, C.X.F. Yang, K. Goh, J.C.H. Hutmacher, D.W. Wong, H.K. |
Keywords: | bone morphogenetic protein bone tissue engineering scaffold design spinal reconstruction stem cells |
Issue Date: | 2009 | Citation: | Abbah, A.S.,Lam, C.X.F.,Yang, K.,Goh, J.C.H.,Hutmacher, D.W.,Wong, H.K. (2009). Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion. IFMBE Proceedings 23 : 1476-1479. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-540-92841-6_365 | Abstract: | The use of metallic fusion cages in lumbar interbody fusion is often associated with serious complications including implant subsidence and corrosion. A bioresorbable scaffold with distinct architectural design has recently been fabricated from medical grade polycaprolactone and betatricalcium phosphate (mPCL-TCP) for bone tissue engineering at weight bearing sites. Porous mPCL-TCP scaffolds demonstrate mechanical and biological properties comparable to cancellous bone and have been shown to enhance new bone formation at ectopic and cranio-facial sites. In this study, we evaluated the fusion performance of mPCL-TCP implants in a porcine model of anterior interbody lumbar fusion (ALIF). Twenty two pigs underwent a two-level (L3/4 and L4/5) ALF surgery in four experimental groups namely, standalone scaffolds, scaffolds + stem cells, scaffolds + rhBMP-2 and bone autograft. Results indicate a significant enhancement in stiffness of motion segments implanted with scaffolds + rhBMP-2 compared to other groups including autografts as early as three months (p | Source Title: | IFMBE Proceedings | URI: | http://scholarbank.nus.edu.sg/handle/10635/88250 | ISBN: | 9783540928409 | ISSN: | 16800737 | DOI: | 10.1007/978-3-540-92841-6_365 |
Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.