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dc.titleFusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion
dc.contributor.authorAbbah, A.S.
dc.contributor.authorLam, C.X.F.
dc.contributor.authorYang, K.
dc.contributor.authorGoh, J.C.H.
dc.contributor.authorHutmacher, D.W.
dc.contributor.authorWong, H.K.
dc.identifier.citationAbbah, A.S.,Lam, C.X.F.,Yang, K.,Goh, J.C.H.,Hutmacher, D.W.,Wong, H.K. (2009). Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion. IFMBE Proceedings 23 : 1476-1479. ScholarBank@NUS Repository. <a href="" target="_blank"></a>
dc.description.abstractThe use of metallic fusion cages in lumbar interbody fusion is often associated with serious complications including implant subsidence and corrosion. A bioresorbable scaffold with distinct architectural design has recently been fabricated from medical grade polycaprolactone and betatricalcium phosphate (mPCL-TCP) for bone tissue engineering at weight bearing sites. Porous mPCL-TCP scaffolds demonstrate mechanical and biological properties comparable to cancellous bone and have been shown to enhance new bone formation at ectopic and cranio-facial sites. In this study, we evaluated the fusion performance of mPCL-TCP implants in a porcine model of anterior interbody lumbar fusion (ALIF). Twenty two pigs underwent a two-level (L3/4 and L4/5) ALF surgery in four experimental groups namely, standalone scaffolds, scaffolds + stem cells, scaffolds + rhBMP-2 and bone autograft. Results indicate a significant enhancement in stiffness of motion segments implanted with scaffolds + rhBMP-2 compared to other groups including autografts as early as three months (p
dc.subjectbone morphogenetic protein
dc.subjectbone tissue engineering
dc.subjectscaffold design
dc.subjectspinal reconstruction
dc.subjectstem cells
dc.typeConference Paper
dc.description.sourcetitleIFMBE Proceedings
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