Please use this identifier to cite or link to this item: https://doi.org/10.1007/978-3-540-92841-6_365
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dc.titleFusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion
dc.contributor.authorAbbah, A.S.
dc.contributor.authorLam, C.X.F.
dc.contributor.authorYang, K.
dc.contributor.authorGoh, J.C.H.
dc.contributor.authorHutmacher, D.W.
dc.contributor.authorWong, H.K.
dc.date.accessioned2014-10-08T09:49:15Z
dc.date.available2014-10-08T09:49:15Z
dc.date.issued2009
dc.identifier.citationAbbah, A.S.,Lam, C.X.F.,Yang, K.,Goh, J.C.H.,Hutmacher, D.W.,Wong, H.K. (2009). Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion. IFMBE Proceedings 23 : 1476-1479. ScholarBank@NUS Repository. <a href="https://doi.org/10.1007/978-3-540-92841-6_365" target="_blank">https://doi.org/10.1007/978-3-540-92841-6_365</a>
dc.identifier.isbn9783540928409
dc.identifier.issn16800737
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88250
dc.description.abstractThe use of metallic fusion cages in lumbar interbody fusion is often associated with serious complications including implant subsidence and corrosion. A bioresorbable scaffold with distinct architectural design has recently been fabricated from medical grade polycaprolactone and betatricalcium phosphate (mPCL-TCP) for bone tissue engineering at weight bearing sites. Porous mPCL-TCP scaffolds demonstrate mechanical and biological properties comparable to cancellous bone and have been shown to enhance new bone formation at ectopic and cranio-facial sites. In this study, we evaluated the fusion performance of mPCL-TCP implants in a porcine model of anterior interbody lumbar fusion (ALIF). Twenty two pigs underwent a two-level (L3/4 and L4/5) ALF surgery in four experimental groups namely, standalone scaffolds, scaffolds + stem cells, scaffolds + rhBMP-2 and bone autograft. Results indicate a significant enhancement in stiffness of motion segments implanted with scaffolds + rhBMP-2 compared to other groups including autografts as early as three months (p
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/978-3-540-92841-6_365
dc.sourceScopus
dc.subjectbone morphogenetic protein
dc.subjectbone tissue engineering
dc.subjectscaffold design
dc.subjectspinal reconstruction
dc.subjectstem cells
dc.typeConference Paper
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1007/978-3-540-92841-6_365
dc.description.sourcetitleIFMBE Proceedings
dc.description.volume23
dc.description.page1476-1479
dc.identifier.isiutNOT_IN_WOS
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