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Title: Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion
Authors: Abbah, A.S.
Lam, C.X.F. 
Yang, K.
Goh, J.C.H.
Hutmacher, D.W.
Wong, H.K.
Keywords: bone morphogenetic protein
bone tissue engineering
scaffold design
spinal reconstruction
stem cells
Issue Date: 2009
Citation: Abbah, A.S.,Lam, C.X.F.,Yang, K.,Goh, J.C.H.,Hutmacher, D.W.,Wong, H.K. (2009). Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion. IFMBE Proceedings 23 : 1476-1479. ScholarBank@NUS Repository.
Abstract: The use of metallic fusion cages in lumbar interbody fusion is often associated with serious complications including implant subsidence and corrosion. A bioresorbable scaffold with distinct architectural design has recently been fabricated from medical grade polycaprolactone and betatricalcium phosphate (mPCL-TCP) for bone tissue engineering at weight bearing sites. Porous mPCL-TCP scaffolds demonstrate mechanical and biological properties comparable to cancellous bone and have been shown to enhance new bone formation at ectopic and cranio-facial sites. In this study, we evaluated the fusion performance of mPCL-TCP implants in a porcine model of anterior interbody lumbar fusion (ALIF). Twenty two pigs underwent a two-level (L3/4 and L4/5) ALF surgery in four experimental groups namely, standalone scaffolds, scaffolds + stem cells, scaffolds + rhBMP-2 and bone autograft. Results indicate a significant enhancement in stiffness of motion segments implanted with scaffolds + rhBMP-2 compared to other groups including autografts as early as three months (p
Source Title: IFMBE Proceedings
ISBN: 9783540928409
ISSN: 16800737
DOI: 10.1007/978-3-540-92841-6_365
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