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|Title:||Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion||Authors:||Abbah, A.S.
|Keywords:||bone morphogenetic protein
bone tissue engineering
|Issue Date:||2009||Citation:||Abbah, A.S.,Lam, C.X.F.,Yang, K.,Goh, J.C.H.,Hutmacher, D.W.,Wong, H.K. (2009). Fusion Performance of a Bioresorbable Cage Used In Porcine Model of Anterior Lumbar Interbody Fusion. IFMBE Proceedings 23 : 1476-1479. ScholarBank@NUS Repository. https://doi.org/10.1007/978-3-540-92841-6_365||Abstract:||The use of metallic fusion cages in lumbar interbody fusion is often associated with serious complications including implant subsidence and corrosion. A bioresorbable scaffold with distinct architectural design has recently been fabricated from medical grade polycaprolactone and betatricalcium phosphate (mPCL-TCP) for bone tissue engineering at weight bearing sites. Porous mPCL-TCP scaffolds demonstrate mechanical and biological properties comparable to cancellous bone and have been shown to enhance new bone formation at ectopic and cranio-facial sites. In this study, we evaluated the fusion performance of mPCL-TCP implants in a porcine model of anterior interbody lumbar fusion (ALIF). Twenty two pigs underwent a two-level (L3/4 and L4/5) ALF surgery in four experimental groups namely, standalone scaffolds, scaffolds + stem cells, scaffolds + rhBMP-2 and bone autograft. Results indicate a significant enhancement in stiffness of motion segments implanted with scaffolds + rhBMP-2 compared to other groups including autografts as early as three months (p||Source Title:||IFMBE Proceedings||URI:||http://scholarbank.nus.edu.sg/handle/10635/88250||ISBN:||9783540928409||ISSN:||16800737||DOI:||10.1007/978-3-540-92841-6_365|
|Appears in Collections:||Staff Publications|
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