Please use this identifier to cite or link to this item: https://doi.org/10.1117/12.647384
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dc.titleClassification of colonic tissues using raman spectroscopy and multivariate techniques
dc.contributor.authorHuang, Z.
dc.contributor.authorZheng, W.
dc.contributor.authorWidjaja, E.
dc.contributor.authorMo, J.
dc.contributor.authorSheppard, C.
dc.date.accessioned2014-10-08T09:49:06Z
dc.date.available2014-10-08T09:49:06Z
dc.date.issued2006
dc.identifier.citationHuang, Z., Zheng, W., Widjaja, E., Mo, J., Sheppard, C. (2006). Classification of colonic tissues using raman spectroscopy and multivariate techniques. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 6093 : -. ScholarBank@NUS Repository. https://doi.org/10.1117/12.647384
dc.identifier.issn16057422
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/88237
dc.description.abstractThe purpose of this study was to explore the feasibility of using near-infrared (NIR) Raman spectroscopy and multivariate techniques for distinguishing cancer from normal and benign tissue in the colon. A total of 105 colonic specimens were used for Raman studies including 41 normal, 18 polyps, and 46 malignant tumors. The multivariate statistical techniques such as PCA-SVM were utilized to extract the significant Raman features and to develop effective diagnostic algorithms for tissue classification. The results showed that high-quality Raman spectra in the 800-1800 cm -1 range can be acquired from human colonic tissues in vitro, and Raman spectra differed significantly between normal, benign and malignant tumor tissue. PCA-SVM yielded a diagnostic sensitivity of 100%, 100%, and 97.7%, and specificity of 99.8%, 100%, and 100%, respectively, for differentiation between normal, polyp, and malignant tissue. Therefore, NIR Raman spectroscopy associated with multivariate techniques provides a significant potential for the noninvasive diagnosis of colonic cancers in vivo based on optical evaluation of biomolecules.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1117/12.647384
dc.sourceScopus
dc.subjectAdenocarcinoma
dc.subjectColon cancer
dc.subjectNear-infrared Raman spectroscopy
dc.subjectOptical diagnosis
dc.subjectPolyp
dc.subjectSupport vector machines
dc.typeConference Paper
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1117/12.647384
dc.description.sourcetitleProgress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.description.volume6093
dc.description.page-
dc.identifier.isiut000237678500021
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