Please use this identifier to cite or link to this item:
Title: Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging
Authors: Jones, A.C.
Milthorpe, B.
Averdunk, H.
Limaye, A.
Senden, T.J.
Sakellariou, A.
Sheppard, A.P.
Sok, R.M.
Knackstedt, M.A.
Brandwood, A.
Rohner, D.
Hutmacher, D.W. 
Keywords: Bone tissue engineering
Image analysis
X-ray micro-computed tomography
Issue Date: Sep-2004
Citation: Jones, A.C., Milthorpe, B., Averdunk, H., Limaye, A., Senden, T.J., Sakellariou, A., Sheppard, A.P., Sok, R.M., Knackstedt, M.A., Brandwood, A., Rohner, D., Hutmacher, D.W. (2004-09). Analysis of 3D bone ingrowth into polymer scaffolds via micro-computed tomography imaging. Biomaterials 25 (20) : 4947-4954. ScholarBank@NUS Repository.
Abstract: This paper illustrates the utility of micro-computed tomography (micro-CT) to study the process of tissue engineered bone growth. A micro-CT facility for imaging and visualising biomaterials in three dimensions (3D) is described. The facility is capable of acquiring 3D images made up of 20003 voxels on specimens up to 60mm in extent with resolutions down to 2μm. This allows the 3D structure of tissue engineered materials to be imaged across three orders of magnitude of detail. The capabilities of micro-CT are demonstrated by imaging the Haversian network within human femoral cortical bone (distal diaphysis) and bone ingrowth into a porous scaffold at varying resolutions. Phase identification combined with 3D visualisation enables one to observe the complex topology of the canalicular system of the cortical bone. Imaging of the tissue engineered bone at a scale of 1cm and resolutions of 10μm allows visualisation of the complex ingrowth of bone into the polymer scaffold. Further imaging at 2μm resolution allows observation of bone ultra-structure. These observations illustrate the benefits of tomography over traditional techniques for the characterisation of bone morphology and interconnectivity and performs a complimentary role to current histomorphometric techniques. © 2004 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2004.01.047
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.