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Title: Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging
Authors: Tan, H. 
Zhang, Y. 
Wang, M.
Zhang, Z.
Zhang, X.
Yong, A.M.
Wong, S.Y.
Chang, A.Y.C.
Chen, Z.-K.
Li, X.
Choolani, M.
Wang, J. 
Keywords: Biomimetic materials
Image analysis
Issue Date: Jan-2012
Citation: Tan, H., Zhang, Y., Wang, M., Zhang, Z., Zhang, X., Yong, A.M., Wong, S.Y., Chang, A.Y.C., Chen, Z.-K., Li, X., Choolani, M., Wang, J. (2012-01). Silica-shell cross-linked micelles encapsulating fluorescent conjugated polymers for targeted cellular imaging. Biomaterials 33 (1) : 237-246. ScholarBank@NUS Repository.
Abstract: A bioinspired silification approach was successfully used to encapsulate fluorescent conjugated polymers inside silica-shell cross-linked polymeric micelles (CP-SSCL) in the highly benign synthesis environment of room temperature and near-neutral aqueous environment. Four different conjugated polymers were employed to demonstrate the versatility of the bioinspired silification, resulting in the formation of CP-SSCL with different emission wavelengths across the visible spectrum. The CP-SSCL are characterized by a large absorption coefficient and high quantum yield, indicating that they exhibit the required high fluorescence brightness for cellular imaging application. In addition, the CP-SSCL also exhibit a high colloidal stability and low cytotoxicity. The in vitro studies of using MDA-MB-231 breast cancer cells show that the CP-SSCL are successfully uptaken by the cancer cells and located at the cytoplasm of the cells. Furthermore, by conjugating folic acid on their surfaces, the uptake of CP-SSCL by MDA-MB-231 cells was enhanced significantly, suggesting their great potential for targeted imaging and early detection of cancer cells. © 2011 Elsevier Ltd.
Source Title: Biomaterials
ISSN: 01429612
Appears in Collections:Staff Publications

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