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Title: Manipulating the surface coating of ultra-small Gd2O3 nanoparticles for improved T1-weighted MR imaging
Authors: Fang, J.
Chandrasekharan, P.
Liu, X.-L.
Yang, Y.
Lv, Y.-B.
Yang, C.-T.
Ding, J. 
Keywords: Contrast agent
Gd2O3 nanoparticles
Ligand exchange
MR imaging
Polyvinyl pyrrolidone
Issue Date: Feb-2014
Citation: Fang, J., Chandrasekharan, P., Liu, X.-L., Yang, Y., Lv, Y.-B., Yang, C.-T., Ding, J. (2014-02). Manipulating the surface coating of ultra-small Gd2O3 nanoparticles for improved T1-weighted MR imaging. Biomaterials 35 (5) : 1636-1642. ScholarBank@NUS Repository.
Abstract: In this report, monodispersed ultra-small Gd2O3 nanoparticles capped with hydrophobic oleic acid (OA) were synthesized with average particle size of 2.9nm. Two methods were introduced to modify the surface coating to hydrophilic for bio-applications. With a hydrophilic coating, the polyvinyl pyrrolidone (PVP) coated Gd2O3 nanoparticles (Gd2O3-PVP) showed a reduced longitudinal T1 relaxation time compared with OA and cetyltrimethylammonium bromide (CTAB) co-coated Gd2O3 (Gd2O3-OA-CTAB) in the relaxation study. The Gd2O3-PVP was thus chosen for its further application study in MRI with an improved longitudinal relaxivity r1 of 12.1mm-1s-1 at 7T, which is around 3 times as that of commercial contrast agent Magnevist®. Invitro cell viability in HK-2 cell indicated negligible cytotoxicity of Gd2O3-PVP within preclinical dosage. Invivo MR imaging study of Gd2O3-PVP nanoparticles demonstrated considerable signal enhancement in the liver and kidney with a long blood circulation time. Notably, the OA capping agent was replaced by PVP through ligand exchange on the Gd2O3 nanoparticle surface. The hydrophilic PVP grants the Gd2O3 nanoparticles with a polar surface for bio-application, and the obtained Gd2O3-PVP could be used as an invivo indicator of reticuloendothelial activity. © 2013 Elsevier Ltd.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2013.11.032
Appears in Collections:Staff Publications

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