Please use this identifier to cite or link to this item: https://doi.org/10.1063/1.3696001
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dc.titleFe 3O 4-citrate-curcumin: Promising conjugates for superoxide scavenging, tumor suppression and cancer hyperthermia
dc.contributor.authorKitture, R.
dc.contributor.authorGhosh, S.
dc.contributor.authorKulkarni, P.
dc.contributor.authorLiu, X.L.
dc.contributor.authorMaity, D.
dc.contributor.authorPatil, S.I.
dc.contributor.authorJun, D.
dc.contributor.authorDushing, Y.
dc.contributor.authorLaware, S.L.
dc.contributor.authorChopade, B.A.
dc.contributor.authorKale, S.N.
dc.date.accessioned2014-10-07T09:49:24Z
dc.date.available2014-10-07T09:49:24Z
dc.date.issued2012-03-15
dc.identifier.citationKitture, R., Ghosh, S., Kulkarni, P., Liu, X.L., Maity, D., Patil, S.I., Jun, D., Dushing, Y., Laware, S.L., Chopade, B.A., Kale, S.N. (2012-03-15). Fe 3O 4-citrate-curcumin: Promising conjugates for superoxide scavenging, tumor suppression and cancer hyperthermia. Journal of Applied Physics 111 (6) : -. ScholarBank@NUS Repository. https://doi.org/10.1063/1.3696001
dc.identifier.issn00218979
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/86327
dc.description.abstractFe 3O 4 nanoparticles have been conjugated to curcumin (CU) molecules via a citrate (CA) linker (Fe-CA-CU) and have been explored for superoxide scavenging, tumor suppression, and cancer hyperthermia. The conjugation chemistry reveals that Fe 3+ ions on the nanoparticle surface readily conjugates to the available carboxyl sites on the CA molecule, which further conjugates to CU at its central enol -OH group. As seen from the UV-vis spectroscopy, the therapeutically active chromophore group of CU, which is seen at 423 nm, was intact, ensuring the activity the molecule. Magnetization measurements showed good hysteresis curves of Fe 3O 4 and Fe-CA-CU, indicating the presence of magnetism after conjugation. The loading percentage of citrate-curcumin was seen to be ∼10 from the thermo-gravimetric analysis. The systems when subjected to radio-frequency fields of 240 KHz, were seen to get heated up. The Fe 3O 4 heating exhibited better slope (1 C/s) as compared to the Fe-CA-CU system (∼0.7 °C/s) for a sample of concentration 10 mg/ml in average time of ∼20 s to reach the required hyperthermia threshold temperature of ∼45 °C. Tumor suppression studies were done using potato assay, which showed that while only CU showed 100 suppression in 7 days, it was about 89 by the Fe-CA-CU. Upon subjecting these systems to the superoxide anion scavenging assay and superoxide radical scavenging assay (riboflavin), it was observed that the activity was enhanced in the Fe-CA-CU to 40 (from 38 in only CU) and 100 (from 5.75 in only CU). These studies promise Fe-CA-CU as a good cancer hyperthermia-cum-tumor suppressant and antioxidant agent. © 2012 American Institute of Physics.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1063/1.3696001
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentMATERIALS SCIENCE AND ENGINEERING
dc.description.doi10.1063/1.3696001
dc.description.sourcetitleJournal of Applied Physics
dc.description.volume111
dc.description.issue6
dc.description.page-
dc.description.codenJAPIA
dc.identifier.isiut000302221700138
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