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Title: Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications
Authors: Maity, D.
Chandrasekharan, P.
Yang, C.-T.
Chuang, K.-H.
Shuter, B.
Xue, J.-M. 
Ding, J. 
Feng, S.-S. 
Keywords: cancer diagnosis and treatment
cellular and molecular imaging
magnetic nanocrystals
magnetic nanothermotherapy
magnetite nanoparticles
superparamagnetic iron oxides
Issue Date: Dec-2010
Citation: Maity, D., Chandrasekharan, P., Yang, C.-T., Chuang, K.-H., Shuter, B., Xue, J.-M., Ding, J., Feng, S.-S. (2010-12). Facile synthesis of water-stable magnetite nanoparticles for clinical MRI and magnetic hyperthermia applications. Nanomedicine 5 (10) : 1571-1584. ScholarBank@NUS Repository.
Abstract: Aims: Superparamagnetic magnetite nanoparticles have been under intensive investigation in nanomedicine. However, it is still a challenge to synthesize high-quality water-stable magnetite nanoparticles for better magnetic performance and less side effects in medical MRI and nanothermotherapy. Materials & methods: We successfully synthesized hydrophilic magnetite nanoparticles through thermal decomposition of Fe(acac)3 in triethylene glycol, which were coated with a triethylene glycol layer and thus demonstrated excellent water stability. Results: The optimized deposition temperature has been found to be 250°C (IO-250 NPs). The magnetic and thermal properties as well as the cytotoxicity of IO-250 NPs were investigated. In vitro experiments have demonstrated high cellular uptake and low cytotoxicity. The hyperthermia experiments showed effectiveness in temperature rise and cancer cell death. IO-250 NPs showed promising MRI with relaxivity r2* as high as 617.5 s-1 mM-1 Fe. In vivo MRI showed excellent tumor imaging. Conclusion: The IO-250 NPs have great potential to be applied for clinical MRI and magnetic thermotherapy. © 2010 Future Medicine Ltd.
Source Title: Nanomedicine
ISSN: 17435889
DOI: 10.2217/nnm.10.77
Appears in Collections:Staff Publications

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