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Title: A novel amperometric biosensor based on ZnO:Co nanoclusters for biosensing glucose
Authors: Zhao, Z.W.
Chen, X.J.
Tay, B.K.
Chen, J.S. 
Han, Z.J.
Khor, K.A.
Keywords: Cross-linking
Glucose biosensor
Issue Date: 30-Aug-2007
Citation: Zhao, Z.W., Chen, X.J., Tay, B.K., Chen, J.S., Han, Z.J., Khor, K.A. (2007-08-30). A novel amperometric biosensor based on ZnO:Co nanoclusters for biosensing glucose. Biosensors and Bioelectronics 23 (1) : 135-139. ScholarBank@NUS Repository.
Abstract: ZnO:Co nanoclusters were synthesized by nanocluster-beam deposition with averaged particle size of 5 nm and porous structure, which were for the first time adopted to construct a novel amperometric glucose biosensor. Glucose oxidase was immobilized into the ZnO:Co nanocluster-assembled thin film through Nafion-assisted cross-linking technique. Due to the high specific active sites and high electrocatalytic activity of the ZnO:Co nanoclusters, the constructed glucose biosensor showed a high sensitivity of 13.3 μA/mA cm2. The low detection limit was estimated to be 20 μM (S/N = 3) and the apparent Michaelis-Menten constant was found to be 21 mM, indicating the high affinity of the enzyme on ZnO:Co nanoclusters to glucose. The results show that the ZnO:Co nanocluster-assembled thin films with nanoporous structure and nanocrystallites have potential applications as platforms to immobilize enzyme in biosensors. © 2007 Elsevier B.V. All rights reserved.
Source Title: Biosensors and Bioelectronics
ISSN: 09565663
DOI: 10.1016/j.bios.2007.03.014
Appears in Collections:Staff Publications

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