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Title: Microdevice for Trapping Circulating Tumor Cells for Cancer Diagnostics
Authors: Tan, S.J.
Yobas, L.
Lee, G.Y.H.
Ong, C.N. 
Lim, C.T. 
Keywords: Cancer metastasis
Cell isolation
Circulating tumor cells
Computational Fluid Dynamics (CFD)
Issue Date: 2009
Citation: Tan, S.J.,Yobas, L.,Lee, G.Y.H.,Ong, C.N.,Lim, C.T. (2009). Microdevice for Trapping Circulating Tumor Cells for Cancer Diagnostics. IFMBE Proceedings 23 : 774-777. ScholarBank@NUS Repository.
Abstract: Cancer metastasis is the main attribute to cancerrelated deaths and early detection is one of the most effective means to treat the disease. Spreading of cancer to distant sites is achieved usually through the circulatory system and the number of circulating tumor cells (CTCs) in peripheral blood is strongly associated to cancer development. Thus detecting CTCs in blood samples will be helpful in identifying susceptible subjects. Here, we propose a label-free technique to isolate these cancerous cells from blood. Using cancer cells spiked in blood samples, isolation efficiency of at least 80% were obtained with high isolation purity. The microdevice also preserved the integrity of the isolated cells to allow further studies to be done on these cells. These results showed a potential effective microdevice for CTCs studies and possible clinical application. © International Federation of Medical and Biological Engineering 2009.
Source Title: IFMBE Proceedings
ISBN: 9783540928409
ISSN: 16800737
DOI: 10.1007/978-3-540-92841-6_190
Appears in Collections:Staff Publications

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